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KMID : 0616120170480030213
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 3 p.213 ~ p.218
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Anticancer Effect of Paedoksans for Oral Squamous Cell Carcinoma and Malignant Pleural Mesothelioma )
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Oh Ha-Na
Kim Hyun-Jung
Chae Jung-Il
Shim Jung-Hyun
Yoon Goo
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Abstract
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In order to search for anticancer agent as therapy of oral squamous cell carcinoma (OSCC) and malignant pleural mesothelioma (MPM) from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. Among the selected traditional prescriptions, only water extracts of paedoksan (敗毒散) showed relatively good cytotoxicity at the concentration of 50ug/ml. Additionally, we evaluated cytotoxicity for various paedoksans and each herbal ingredient in paedoksans. The root of Anthriscus sylvestris exhibited more cytotoxic effect than any other ingredients in paedoksans. Bioactivity-guided fractionation of the MC layer of Anthriscus sylvestris led to the isolation of deoxypodophyllotoxin (DPT). DPT exhibited dose-dependently significant cytotoxicity against OSCC and MPM cell with nM range. Therefore, DPT from A. sylvestris might be a potential candidate as an effective anticancer therapeutic agent for OSCC and MPM.
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KEYWORD
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Oral squamous cell carcinoma (OSCC) , Malignant pleural mesothelioma (MPM) , Paedoksan , Anthriscus sylvestris , Deoxypodophyllotoxin
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